He covered both the Democratic and Republican National Conventions, where he interviewed politicians including First Lady Michelle Obama, former Speaker of the House Nancy Pelosi, and former Republican Presidential nominee John McCain. Leading up to the 2012 Presidential Election, Mathews was the official political reporter for E! News.

It was also announced in summer 2011 that Mathews had signed a talent deal with the E! Network, to increase his presence at the network. Many of his tour dates were documented on E! News' political series Pop & Politics. In 2011, Mathews began a national college tour speaking about his experiences climbing the Hollywood ladder and discussing his humorous take on pop culture. Inside Dish eventually became the official web show for CBS hits Big Brother, and the Emmy Award winning series The Amazing Race. In 2009, Mathews hosted and executive produced a daily web talk show for The Insider and CBS.com called Inside Dish with Ross Mathews, a show about covering Hollywood from the outside in. In addition to Man Up and Hello Ross!, Mathews can be seen as a regular panelist and occasional guest host on E!'s late-night talk show Chelsea Lately, and is a fixture on E! News and E! Network's live red carpet awards show coverage. With an introduction written by Gwyneth Paltrow, and afterword from Chelsea Handler, Man Up takes readers inside Mathews' personal journey as a super fan, revealing the most embarrassing and hilarious moments of his small town life and big city adventures, and how he managed to turn an obsession with pop culture into one on one interactions with celebrities like Paltrow, Tiffani-Amber Thiessen, Madonna, and Michelle Kwan without ever having a single restraining order issued against him. In 2013, Mathews released his first book, Man Up: Tales of My Delusional Self-Confidence which quickly became a national bestseller. Mathews was also recently nominated for a 2014 People's Choice Award, for 'Favorite New Talk Show Host.' Hello Ross! is the weekly fan destination where the intersections of celebrity gossip and pop culture collide, giving a unique viewpoint into the latest Hollywood news. Mathews can currently be seen hosting the smash hit, talk show Hello Ross!, for E!, season two premiered on February 21, 2014. Endearing and witty, undeniably funny and one of the hardest working people in show business, Mathews has won the hearts of millions of Americans since his television debut - as a correspondent for The Tonight Show with Jay Leno. Since 2001, Ross Mathews has traveled the world and established himself as one of the most in-demand television personalities and entertainment correspondents in the pop-culture arena today.

Man Up! by Ross Mathews